Symbol
Name
ID

Spred1
sprouty protein with EVH-1 domain 1, related sequence
MGI:2150016

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Acute monocytic leukemia
Disease(s) Associated with SPRED1	Acute monocytic leukemia
Legius syndrome

Mouse Phenotypes

increased mast cell degranulation

abnormal thymus morphology

enlarged thymus

enlarged spleen

increased spleen weight

increased eosinophil cell number

increased mast cell number

increased neutrophil cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased effector memory CD8-positive, alpha-beta T cell number

increased memory-marker CD4-positive NK T cell number

increased CD4-positive NK T cell number

increased NK T cell number

increased effector memory T-helper cell number

decreased lymphocyte cell number

abnormal spleen morphology

abnormal eosinophil physiology

Availability

Mouse Genotype

Spred1^{em1(IMPC)Ccpcz}/Spred1^{em1(IMPC)Ccpcz}

Spred1^tm1.1Ayos/Spred1^tm1.1Ayos

Spred1^tm1Hiin/Spred1^tm1Hiin

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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